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APO-AMIODARONE TABLETS and APO-SIMVASTATIN

Posted 4 months ago by John Sollazzo ( HIGH significance )

Respective ATC Codes

C01BD01 and C10AA01

Details

Increased risk of rhabdomyolysis of patients on simvastatin who are also treated with amiodarone because amiodarone inhibits CYP3A4

Effect

Augments

Evidence

Good

Reference

http://www.fda.gov/cder/drug/InfoSheets/HCP/sim...

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