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Vaginitis

Posted Thursday 27 September 2007 - 15:09 PM by Deborah Chan

First Line Drugs

  1. CLOTRIMAZOLE (S01EB01)

  2. APO-FLUCONAZOLE 100MG (J02AC01)

  3. APO-METRONIDAZOLE (J01XD01)

Second Line Drugs

  1. GEN-FLUCONAZOLE 150MG CAPSULE (J02AC01)

  2. APO-METRONIDAZOLE (J01XD01)

For Pregnant Women, Suggest

  1. APO-CLINDAMYCIN 300MG (J01FF01)

  2. CLOTRIMAZOLE CREAM USP 1% (D01AC01)

Reference

http://oscarmcmaster.org:25300/oscarResource-Pl...

Comments/Instructions

1. Candidiasis (antifungicide)

i. Acute

clotrimazole
200 mg tablet intravaginally, hs x 3 days
$9.06/3 days

or clotrimazole
500 mg tablet intravaginally, one time
$9.06/dose

or miconazole
400 mg ovule intravaginally, hs x 3 days
$9.78/3 days

or tioconazole

6.5% ointment
5 g intravaginally, one time
$10.33/dose

or terconazole
80 mg vaginal suppository, hs x3 days
$17.52/3 days

or terconazole

0.8% cream
5 g intravaginally, hs x 3 days
$18.62/3 days

ii. Recurrent (4 or more episodes per year)

fluconazole
100 mg, once weeklyx 6 months
$4.40/week

or ketoconazole
100 mg, once daily x 6 months
$6.58/week

or clotrimazole
500 mg, tablet intravaginally once weekly x 6 months
$9.06/week

or itraconazole
50-100 mg, once dailyx 6 months
$12.25-24.50/week

2. Bacterial vaginosis

metronidazole
2 x 250 mg tablets, bid x 7 days
$0.78/week

or metronidazole gel 0.75%
5 g intravaginally, bid x 5 days
$17.43/30 g

or clindamycin 2% cream
5 g intravaginally, once daily x 7 days
$23.31/week

3. Trichomoniasis

metronidazole
2 g (250 mg x 8 tablets), single dose
$0.22/dose

4. Atrophic,

see Menopausal symptoms

Second-line therapies:

1. Candidiasis

fluconazole
150 mg, single dose
$14.58/dose

2. Bacterial

i. If pregnant

clindamycin
300 mg, bid x 7 days
$21.73/week

ii. Non-pregnant

metrondiazole
2 g (250 mg x 8 tablets) single dose
$0.22/dose

3. Trichomoniasis, if patient in first trimester of pregnancy

clotrimazole 1% cream
5 g intravaginally, once daily x6 days
$5.44/6 days

or clotrimazole
100 mg vaginal inserts, once daily x 6 days(may suppress symptoms)
$9.06/6 days

4. Trichomoniasis, if patient lactating

metronidazole
2 g (250 mg x 8 tablets), single dose
$0.22/dose

Additional instructions and notes

-If candidiasis is asymptomatic, treatment is unnecessary.

-In trichomoniasis, partners should be treated to prevent reinfection.

-Some experts suggest interrupting breast-feeding until 24 h after completing therapy for trichomoniasis.

-Fluconazole is contraindicated in pregnancy.

-Although single-dose metronidazole achieves the same immediate rate of clinical response as does a week course of metronidazole in the treatment of bacterial vaginitis, higher rates of recurrence have been reported.

-Metronidazole does not appear to be associated with an increased teratogenic risk and depending on the risk - benefit ratio could be used in pregnancy.

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