Vaginitis
First Line Drugs
- CLOTRIMAZOLE (S01EB01)
- APO-FLUCONAZOLE 100MG (J02AC01)
- APO-METRONIDAZOLE (J01XD01)
Second Line Drugs
- GEN-FLUCONAZOLE 150MG CAPSULE (J02AC01)
- APO-METRONIDAZOLE (J01XD01)
For Pregnant Women, Suggest
- APO-CLINDAMYCIN 300MG (J01FF01)
- CLOTRIMAZOLE CREAM USP 1% (D01AC01)
Reference
Comments/Instructions
1. Candidiasis (antifungicide)
i. Acute
clotrimazole
200 mg tablet intravaginally, hs x 3 days
$9.06/3 days
or clotrimazole
500 mg tablet intravaginally, one time
$9.06/dose
or miconazole
400 mg ovule intravaginally, hs x 3 days
$9.78/3 days
or tioconazole
6.5% ointment
5 g intravaginally, one time
$10.33/dose
or terconazole
80 mg vaginal suppository, hs x3 days
$17.52/3 days
or terconazole
0.8% cream
5 g intravaginally, hs x 3 days
$18.62/3 days
ii. Recurrent (4 or more episodes per year)
fluconazole
100 mg, once weeklyx 6 months
$4.40/week
or ketoconazole
100 mg, once daily x 6 months
$6.58/week
or clotrimazole
500 mg, tablet intravaginally once weekly x 6 months
$9.06/week
or itraconazole
50-100 mg, once dailyx 6 months
$12.25-24.50/week
2. Bacterial vaginosis
metronidazole
2 x 250 mg tablets, bid x 7 days
$0.78/week
or metronidazole gel 0.75%
5 g intravaginally, bid x 5 days
$17.43/30 g
or clindamycin 2% cream
5 g intravaginally, once daily x 7 days
$23.31/week
3. Trichomoniasis
metronidazole
2 g (250 mg x 8 tablets), single dose
$0.22/dose
4. Atrophic,
see Menopausal symptoms
Second-line therapies:
1. Candidiasis
fluconazole
150 mg, single dose
$14.58/dose
2. Bacterial
i. If pregnant
clindamycin
300 mg, bid x 7 days
$21.73/week
ii. Non-pregnant
metrondiazole
2 g (250 mg x 8 tablets) single dose
$0.22/dose
3. Trichomoniasis, if patient in first trimester of pregnancy
clotrimazole 1% cream
5 g intravaginally, once daily x6 days
$5.44/6 days
or clotrimazole
100 mg vaginal inserts, once daily x 6 days(may suppress symptoms)
$9.06/6 days
4. Trichomoniasis, if patient lactating
metronidazole
2 g (250 mg x 8 tablets), single dose
$0.22/dose
Additional instructions and notes
-If candidiasis is asymptomatic, treatment is unnecessary.
-In trichomoniasis, partners should be treated to prevent reinfection.
-Some experts suggest interrupting breast-feeding until 24 h after completing therapy for trichomoniasis.
-Fluconazole is contraindicated in pregnancy.
-Although single-dose metronidazole achieves the same immediate rate of clinical response as does a week course of metronidazole in the treatment of bacterial vaginitis, higher rates of recurrence have been reported.
-Metronidazole does not appear to be associated with an increased teratogenic risk and depending on the risk - benefit ratio could be used in pregnancy.
Tags
- Obstetrics and Gynecology

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