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Ritonavir

Ritonavir

ATC Code: J05AE03

Saquinavir

ATC Code: J05AE01

Warning

FDA Says HIV Drug Combo Might Carry Cardiac Risks Patients taking two particular HIV antivirals in combination may be at risk for arrhythmias, the FDA warns. The agency reports that the combination of Invirase (saquinavir) and Norvir (ritonavir) may lead to prolonged QT or PR intervals in some patients. The FDA says its review is ongoing, but warns that the combination "should not be used in patients already taking medications known to cause QT interval prolongation ... or in patients with a history of QT interval prolongation."

Evidence

Good

Reference